VAV3, vav guanine nucleotide exchange factor 3

VAV3, vav guanine nucleotide exchange factor 3

• This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (guanine nucleotide exchange factor VAV3, VAV-3, vav 3 guanine nucleotide exchange factor, vav 3 oncogene,)
• NCBI Gene ID: 10451
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UKW4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

vav guanine nucleotide exchange factor 3 interacts with:

• B cell linker
  RAD50 interactor 1
  zinc finger RANBP2-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.