CLP1, cleavage factor polyribonucleotide kinase subunit 1

CLP1, cleavage factor polyribonucleotide kinase subunit 1

• This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

• Gene Synonyms (HEAB, hClp1, polyribonucleotide 5'-hydroxyl-kinase Clp1, ATP/GTP-binding protein, cleavage and polyadenylation factor I subunit 1, homolog of yeast CFIA subunit Clp1p, polyadenylation factor Clp1, polynucleotide kinase Clp1, pre-mRNA cleavage complex II protein Clp1,)
• NCBI Gene ID: 10978
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q92989
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cleavage factor polyribonucleotide kinase subunit 1 interacts with:

• centromere protein E
  centrosomal protein 164
  cleavage and polyadenylation specific factor 2
  cleavage and polyadenylation specific factor 3
  cleavage and polyadenylation specific factor 6
  cleavage and polyadenylation specific factor 7
  CLP1, cleavage and polyadenylation factor I subunit
  coiled-coil domain containing 130
  diacylglycerol lipase beta
  FTO alpha-ketoglutarate dependent dioxygenase
  hemicentin 1
  mesoderm development LRP chaperone
  metallo-beta-lactamase domain containing 1
  nudix hydrolase 21
  PCF11 cleavage and polyadenylation factor subunit
  proline rich 3
  ribosomal protein L35
  SNF8 subunit of ESCRT-II
  SNW domain containing 1
  trinucleotide repeat containing adaptor 6A
  tRNA splicing endonuclease subunit 15
  tRNA splicing endonuclease subunit 2
  tRNA splicing endonuclease subunit 34
  tRNA splicing endonuclease subunit 54

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.