COL4A5, collagen type IV alpha 5 chain

COL4A5, collagen type IV alpha 5 chain

• This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]

• Gene Synonyms (collagen alpha-5(IV) chain, collagen IV, alpha-5 polypeptide, collagen of basement membrane, alpha-5 chain, collagen, type IV, alpha 5, dA149D17.3, dA24A23.1, ASLN, ATS, ATS1, CA54,)
• NCBI Gene ID: 1287
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A7MBN3
  UNIPROT ID#>>P29400
  UNIPROT ID#>>Q49AM6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

collagen type IV alpha 5 chain interacts with:

• abhydrolase domain containing 4, N-acyl phospholipase B
  ANTXR cell adhesion molecule 2
  barttin CLCNK type accessory subunit beta
  CD93 molecule
  ceramide synthase 4
  claudin 7
  collagen beta(1-O)galactosyltransferase 2
  collagen type VIII alpha 2 chain
  DAZ associated protein 2
  death associated protein 3
  decorin
  ELAV like RNA binding protein 1
  ELOVL fatty acid elongase 4
  ERGIC and golgi 3
  estrogen related receptor, beta
  family with sequence similarity 209 member A
  fibronectin 1
  fibulin 2
  free fatty acid receptor 2
  glutathione peroxidase 8 (putative)
  heterogeneous nuclear ribonucleoprotein L
  hyaluronan binding protein 2
  kinesin family member 21B
  kinetochore scaffold 1
  lectin, galactoside-binding, soluble, 3 binding protein
  matrilin 2
  matrix metallopeptidase 9
  mitochondrial fission factor
  mitochondrial translational initiation factor 3
  natural killer cell cytotoxicity receptor 3 ligand 1
  nuclear envelope integral membrane protein 1
  nuclear receptor subfamily 1 group H member 2
  oncostatin M
  potassium inwardly rectifying channel subfamily J member 6
  procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
  pyruvate dehydrogenase kinase 1
  RELT like 2
  ring finger protein 10
  secretion associated Ras related GTPase 1A
  serpin family E member 2
  solute carrier family 10 member 4
  solute carrier family 10 member 6
  solute carrier family 16 member 2
  solute carrier family 18 member A1
  solute carrier family 35 member C2
  solute carrier family 39 member 2
  striatin 3
  survival of motor neuron 1, telomeric
  THAP domain containing 4
  thymidine kinase 1
  translocator protein 2
  transmembrane protein 80
  von Hippel-Lindau tumor suppressor
  VPS26, retromer complex component B
  WASH complex subunit 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.