Grb2, growth factor receptor bound protein 2

Grb2, growth factor receptor bound protein 2

• The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]

• (No alternate names found)
• NCBI Gene ID: 14784
• Species: Mus musculus (Mouse)
• UNIPROT ID#>>Q60631
  UNIPROT ID#>>Q3U1Q4
  UNIPROT ID#>>Q3U5I5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

growth factor receptor bound protein 2 interacts with:

• autophagy related 16-like 1 (S. cerevisiae)
  AXL receptor tyrosine kinase
  B and T lymphocyte associated
  B cell linker
  BCR activator of RhoGEF and GTPase
  BRISC and BRCA1 A complex member 2
  BRISC complex subunit
  COP9 signalosome subunit 3
  copine II
  DnaJ heat shock protein family (Hsp40) member B11
  docking protein 3
  Fanconi anemia, complementation group D2
  fibroblast growth factor receptor substrate 2
  hyperpolarization-activated, cyclic nucleotide-gated K+ 2
  keratin 36
  keratin 90
  KH domain containing, RNA binding, signal transduction associated 1
  kinase insert domain protein receptor
  KIT proto-oncogene receptor tyrosine kinase
  leucine-rich repeat kinase 1
  lymphocyte cytosolic protein 2
  met proto-oncogene
  microtubule associated monooxygenase, calponin and LIM domain containing 1
  mitogen-activated protein kinase kinase kinase kinase 1
  mitogen-activated protein kinase kinase kinase kinase 4
  musashi RNA-binding protein 2
  myosin, heavy polypeptide 9, non-muscle
  NCK interacting protein with SH3 domain
  nerve growth factor receptor (TNFR superfamily, member 16)
  neurofibromin 2
  nitrogen fixation gene 1 (S. cerevisiae)
  OTU deubiquitinase 4
  PDZ and LIM domain 5
  phosphoinositide-3-kinase regulatory subunit 1
  phospholipase C, gamma 1
  phospholipase C, gamma 2
  platelet derived growth factor receptor, beta polypeptide
  prion protein
  protein tyrosine phosphatase, non-receptor type 11
  protein tyrosine phosphatase, non-receptor type 18
  protein tyrosine phosphatase, non-receptor type 23
  protein tyrosine phosphatase, non-receptor type 6
  protein tyrosine phosphatase, receptor type, A
  protein tyrosine phosphatase, receptor type, N polypeptide 2
  RalBP1 associated Eps domain containing protein
  sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
  serine/threonine kinase 32C
  SH2B adaptor protein 2
  SH3 and multiple ankyrin repeat domains 3
  SH3-domain binding protein 1
  SH3-domain kinase binding protein 1
  Sh3kbp1 binding protein 1
  SHC (Src homology 2 domain containing) transforming protein 2
  shroom family member 2
  solute carrier family 1 (glial high affinity glutamate transporter), member 2
  SOS Ras/Rac guanine nucleotide exchange factor 1
  sprouty RTK signaling antagonist 1
  sprouty RTK signaling antagonist 2
  sprouty RTK signaling antagonist 3
  sprouty RTK signaling antagonist 4
  src homology 2 domain-containing transforming protein C1
  START domain containing 10
  synaptophysin
  TEK receptor tyrosine kinase
  tubby bipartite transcription factor
  WD and tetratricopeptide repeats 1
  Y box protein 1
  zinc finger protein 106

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.