DCLK2, doublecortin like kinase 2

DCLK2, doublecortin like kinase 2

• This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]

• Gene Synonyms (serine/threonine-protein kinase DCLK2, CaMK-like CREB regulatory kinase 2, doublecortin and CaM kinase-like 2, doublecortin domain-containing protein 3B, doublecortin-like and CAM kinase-like 2, CL2, CLICK-II, CLICK2, CLIK2, DCAMKL2, DCDC3, DCDC3B, DCK2,)
• NCBI Gene ID: 166614
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8N568
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

doublecortin like kinase 2 interacts with:

• coiled-coil domain containing 57

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