RCAN1, regulator of calcineurin 1

RCAN1, regulator of calcineurin 1

• The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

• Gene Synonyms (ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1, calcipressin-1, Down syndrome candidate region 1, Down syndrome critical region gene 1, calcium and oxidant-inducible mRNA, modulatory calcineurin-interacting protein 1, myocyte-enriched calcineurin-interacting protein 1, near DSCR proline-rich protein,)
• NCBI Gene ID: 1827
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P53805
  UNIPROT ID#>>B7Z1F0
  UNIPROT ID#>>Q6FGP2
  UNIPROT ID#>>V9GYW9
  UNIPROT ID#>>Q6ZMM3
  UNIPROT ID#>>E9PDJ2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

regulator of calcineurin 1 interacts with:

• acidic residue methyltransferase 1
  beta-transducin repeat containing E3 ubiquitin protein ligase
  C-type lectin domain family 3 member A
  family with sequence similarity 122A
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 4
  glycogen synthase kinase 3 alpha
  glycogen synthase kinase 3 beta
  heat shock protein 90 alpha family class A member 1
  interleukin 1 receptor associated kinase 1
  mitogen-activated protein kinase 3
  mitogen-activated protein kinase kinase kinase 3
  protein phosphatase 3 catalytic subunit alpha
  protein phosphatase 3 catalytic subunit beta
  protein phosphatase 3 catalytic subunit gamma
  protein phosphatase 3 regulatory subunit B, alpha
  S1 RNA binding domain 1
  signal transducer and activator of transcription 2
  TNF receptor associated factor 6
  toll interacting protein
  tripartite motif containing 25
  ubiquitin specific peptidase 22
  ubiquitously expressed prefoldin like chaperone
  zymogen granule protein 16B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.