PIK3R5, phosphoinositide-3-kinase regulatory subunit 5

PIK3R5, phosphoinositide-3-kinase regulatory subunit 5

• Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]

• Gene Synonyms (phosphoinositide 3-kinase regulatory subunit 5, PI3-kinase p101 subunit, phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit, protein FOAP-2, ptdIns-3-kinase p101, F730038I15Rik, FOAP-2, P101-PI3K, p101,)
• NCBI Gene ID: 23533
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8WYR1
  UNIPROT ID#>>L7RT34
  UNIPROT ID#>>J3KSW1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphoinositide-3-kinase regulatory subunit 5 interacts with:

• G protein subunit gamma 2
  sorting nexin 9

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