CENPI, centromere protein I

CENPI, centromere protein I

• This gene encodes a centromere protein that is a component of the CENPA-NAC (nucleosome-associated) complex. This complex is critical for accurate chromosome alignment and segregation and it ensures proper mitotic progression. This protein regulates the recruitment of kinetochore-associated proteins that are required to generate the spindle checkpoint signal. The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. Mutations in this gene may be involved in human X-linked disorders of gonadal development and gametogenesis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jan 2016]

• Gene Synonyms (CENP-I, FSHPRH1, LRPR1, centromere protein I, FSH primary response 1, follicle-stimulating hormone primary response protein, interphase centromere complex protein 19, leucine-rich primary response protein 1,)
• NCBI Gene ID: 2491
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q92674
  UNIPROT ID#>>A0A024RCG4
  UNIPROT ID#>>B4DZL4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

centromere protein I interacts with:

• centromere protein H
  centromere protein H
  centromere protein M
  centromere protein N
  centromere protein O
  centromere protein P
  centromere protein Q
  centromere protein U
  centrosomal protein 76
  DGCR8 microprocessor complex subunit
  integrin subunit beta 3 binding protein
  nucleolar protein interacting with the FHA domain of MKI67
  ring finger protein 4
  RNA binding motif protein 34
  vir like m6A methyltransferase associated
  zinc finger protein 71

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.