GCLM, glutamate-cysteine ligase modifier subunit

GCLM, glutamate-cysteine ligase modifier subunit

• Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

• Gene Synonyms (glutamate--cysteine ligase regulatory subunit, GCS light chain, GSC light chain, gamma-ECS regulatory subunit, gamma-glutamylcysteine synthetase regulatory subunit, glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD), glutamate-cysteine ligase modifier subunit delta2 alternative splicing, glutamate-cysteine ligase regulatory protein, GLCLR,)
• NCBI Gene ID: 2730
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P48507
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glutamate-cysteine ligase modifier subunit interacts with:

• AAR2 splicing factor
  copine 3
  cullin 3
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  G protein subunit alpha i2
  glutaredoxin 3
  interferon regulatory factor 7
  N-acetylglucosamine kinase
  ninein
  nuclear receptor subfamily 2 group C member 2
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  oxidative stress induced growth inhibitor 1
  PIH1 domain containing 1
  plasminogen activator, urokinase receptor
  pleckstrin homology domain containing A4
  poly(ADP-ribose) polymerase family member 12
  protein kinase C alpha
  ribosomal protein S6 kinase A1
  sorbitol dehydrogenase
  storkhead box 1
  transient receptor potential cation channel subfamily V member 5
  tripartite motif containing 14
  uroporphyrinogen III synthase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.