HBG1, hemoglobin subunit gamma 1

HBG1, hemoglobin subunit gamma 1

• The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]

• Gene Synonyms (hemoglobin subunit gamma-1, A-gamma globin, gamma A hemoglobin, gamma globin, gamma-1-globin, hb F Agamma, hemoglobin gamma-1 chain, hemoglobin gamma-a chain, hemoglobin, gamma A, hemoglobin, gamma, regulator of, HBG-T2, HBGA, HBGR, HSGGL1, PRO2979,)
• NCBI Gene ID: 3047
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P69891
  UNIPROT ID#>>D9YZU8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

hemoglobin subunit gamma 1 interacts with:

• BAG cochaperone 3
  double PHD fingers 2
  GABA type A receptor associated protein like 2
  integrin subunit alpha 4
  keratin associated protein 10-3
  keratin associated protein 10-9
  minichromosome maintenance complex component 2
  NRAS proto-oncogene, GTPase
  vascular cell adhesion molecule 1
  zinc finger DHHC-type palmitoyltransferase 17

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.