HOXD8, homeobox D8

HOXD8, homeobox D8

• This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

• Gene Synonyms (homeobox protein Hox-D8, Hox-4.5, homeo box 4E, homeo box D8, homeobox protein 5.4, homeobox protein Hox-4E, homeobox protein Hox-5.4, HOX4, HOX4E, HOX5.4,)
• NCBI Gene ID: 3234
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P13378
  UNIPROT ID#>>A0A0A0MSX5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

homeobox D8 interacts with:

• BAR/IMD domain containing adaptor protein 2
  low density lipoprotein receptor adaptor protein 1
  NCK adaptor protein 2
  prefoldin subunit 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.