HPN, hepsin

HPN, hepsin

• This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

• Gene Synonyms (serine protease hepsin, testicular tissue protein Li 85, transmembrane protease serine 1, TMPRSS1,)
• NCBI Gene ID: 3249
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P05981
  UNIPROT ID#>>B7Z1L4
  UNIPROT ID#>>A0A140VJK9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

hepsin interacts with:

• surfactant protein C
  uroplakin 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.