APOC3, apolipoprotein C3

APOC3, apolipoprotein C3

• This gene encodes a protein component of triglyceride (TG)-rich lipoproteins (TRLs) including very low density lipoproteins (VLDL), high density lipoproteins (HDL) and chylomicrons. The encoded protein plays a role in role in the metabolism of these TRLs through multiple modes. This protein has been shown to promote the secretion of VLDL1, inhibit lipoprotein lipase enzyme activity, and delay catabolism of TRL remnants. Mutations in this gene are associated with low plasma triglyceride levels and reduced risk of ischemic cardiovascular disease, and hyperalphalipoproteinemia, which is characterized by elevated levels of high density lipoprotein (HDL) and HDL cholesterol in human patients. This gene and other related genes comprise an apolipoprotein gene cluster on chromosome 11. [provided by RefSeq, Sep 2017]

• Gene Synonyms (apolipoprotein C-III, APOCIII,)
• NCBI Gene ID: 345
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A3KPE2
  UNIPROT ID#>>P02656
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

apolipoprotein C3 interacts with:

• ADP ribosylation factor GTPase activating protein 1
  armadillo repeat containing 12
  ERGIC and golgi 3
  family with sequence similarity 209 member A
  glutathione peroxidase 8 (putative)
  SRY-box transcription factor 4
  testis expressed 101
  vitamin K epoxide reductase complex subunit 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.