IGFBP2, insulin like growth factor binding protein 2

IGFBP2, insulin like growth factor binding protein 2

• The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]

• Gene Synonyms (insulin-like growth factor-binding protein 2, IGF-binding protein 2, insulin-like growth factor binding protein 2, 36kDa, IBP2, IGF-BP53,)
• NCBI Gene ID: 3485
• Species: Homo sapiens (Human)
• UNIPROT ID#>>C9JMY1
  UNIPROT ID#>>P18065
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

insulin like growth factor binding protein 2 interacts with:

• gasdermin B
  INO80 complex subunit B
  kallikrein related peptidase 2
  transferrin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.