IDO1, indoleamine 2,3-dioxygenase 1

IDO1, indoleamine 2,3-dioxygenase 1

• This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

• Gene Synonyms (indoleamine 2,3-dioxygenase 1, indolamine 2,3 dioxygenase, indole 2,3-dioxygenase, indoleamine-pyrrole 2,3-dioxygenase, IDO, IDO-1, INDO,)
• NCBI Gene ID: 3620
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P14902
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

indoleamine 2,3-dioxygenase 1 interacts with:

• DEAD-box helicase 24
  protein phosphatase 1 regulatory subunit 16A
  TERF2 interacting protein

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