LBP, lipopolysaccharide binding protein

LBP, lipopolysaccharide binding protein

• The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]

• Gene Synonyms (BPIFD2, lipopolysaccharide-binding protein, BPI fold containing family D, member 2, LPS-binding protein,)
• NCBI Gene ID: 3929
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P18428
  UNIPROT ID#>>Q8TCF0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lipopolysaccharide binding protein interacts with:

• BAG cochaperone 6
  CBFA2/RUNX1 partner transcriptional co-repressor 2
  peroxiredoxin 4
  proteasome 20S subunit alpha 3
  pyrroline-5-carboxylate reductase 3
  ribosomal protein S21
  SET domain containing 1A, histone lysine methyltransferase
  SMAD family member 3
  transformer 2 alpha homolog
  TSC22 domain family member 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.