LTA4H, leukotriene A4 hydrolase

LTA4H, leukotriene A4 hydrolase

• The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

• Gene Synonyms (leukotriene A-4 hydrolase, LTA-4 hydrolase, testicular secretory protein Li 27,)
• NCBI Gene ID: 4048
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P09960
  UNIPROT ID#>>A0A140VK27
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

leukotriene A4 hydrolase interacts with:

• actin related protein 2/3 complex subunit 3
  anterior gradient 2, protein disulphide isomerase family member
  DET1 and DDB1 associated 1
  histone deacetylase 5
  MCC regulator of WNT signaling pathway
  neurotrophic receptor tyrosine kinase 1
  nicotinate phosphoribosyltransferase
  phosphoglucomutase 1
  pre-mRNA processing factor 4
  ring finger protein 123
  RIO kinase 1
  sepiapterin reductase
  sirtuin 1
  sirtuin 7
  TERF1 interacting nuclear factor 2
  TNF receptor associated protein 1
  transgelin 2
  transmembrane protein 62
  ubiquitin like modifier activating enzyme 5
  zinc finger protein 593

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.