MARS1, methionyl-tRNA synthetase 1

MARS1, methionyl-tRNA synthetase 1

• This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]

• Gene Synonyms (CMT2U, ILFS2, ILLD, MARS, METRS, MRS, MTRNS, SPG70, methionine--tRNA ligase, cytoplasmic, cytosolic methionyl-tRNA synthetase,)
• NCBI Gene ID: 4141
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P56192
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

methionyl-tRNA synthetase 1 interacts with:

• AAR2 splicing factor
  aminoacyl tRNA synthetase complex interacting multifunctional protein 1
  aminoacyl tRNA synthetase complex interacting multifunctional protein 2
  anterior gradient 2, protein disulphide isomerase family member
  arginyl-tRNA synthetase 1
  ataxin 3
  autophagy related 16 like 1
  BRF2 RNA polymerase III transcription initiation factor subunit
  bromodomain containing 7
  calcium/calmodulin dependent serine protein kinase
  chaperonin containing TCP1 subunit 3
  coenzyme Q2, polyprenyltransferase
  coiled-coil domain containing 8
  cullin 1
  cullin 3
  cullin 7
  cytokine induced apoptosis inhibitor 1
  developmental pluripotency-associated 3
  early endosome antigen 1
  elongation factor Tu GTP binding domain containing 2
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation elongation factor 1 epsilon 1
  F-box and WD repeat domain containing 7
  F-box protein 25
  F-box protein 6
  G3BP stress granule assembly factor 1
  GIPC PDZ domain containing family member 1
  glutamate rich WD repeat containing 1
  glutaminyl-tRNA synthetase 1
  heat shock protein 90 beta family member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heterogeneous nuclear ribonucleoprotein U like 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 5
  integrin alpha FG-GAP repeat containing 1
  kinectin 1
  LEO1 homolog, Paf1/RNA polymerase II complex component
  leucyl-tRNA synthetase 1
  leukocyte receptor cluster member 1
  ligand of numb-protein X 1
  limb development membrane protein 1 like
  MAF bZIP transcription factor K
  MCC regulator of WNT signaling pathway
  metastasis associated 1
  minichromosome maintenance complex component 2
  MYC proto-oncogene, bHLH transcription factor
  N-alpha-acetyltransferase 20, NatB catalytic subunit
  neurotrophic receptor tyrosine kinase 1
  neutrophil cytosolic factor 1
  N-myristoyltransferase 1
  nuclear receptor subfamily 2 group C member 2
  nuclear transcription factor, X-box binding 1
  oxidative stress responsive kinase 1
  peptidylprolyl cis/trans isomerase, NIMA-interacting 4
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 8
  prohibitin
  protein kinase AMP-activated non-catalytic subunit beta 1
  protein kinase N2
  protein phosphatase 2 scaffold subunit Aalpha
  protein phosphatase, Mg2+/Mn2+ dependent 1F
  pyrimidinergic receptor P2Y6
  pyruvate dehydrogenase E1 subunit alpha 1
  RAD18 E3 ubiquitin protein ligase
  RecQ like helicase 4
  regulator of chromosome condensation 2
  ribosomal protein L13
  ribosomal protein L27a
  ribosomal protein L35
  ribosomal protein lateral stalk subunit P0
  ribosomal protein S27
  ring finger protein 2
  ring finger protein 4
  RIO kinase 1
  serologically defined colon cancer antigen 8
  small nuclear RNA activating complex polypeptide 1
  staufen double-stranded RNA binding protein 1
  syndecan binding protein
  taxilin alpha
  thymopoietin
  TNF superfamily member 13b
  transcription factor CP2
  treacle ribosome biogenesis factor 1
  tRNA methyltransferase 6
  tRNA methyltransferase 61A
  troponin T1, slow skeletal type
  ubiquilin 2
  ubiquitin specific peptidase 14
  unc-93 homolog B1, TLR signaling regulator
  valyl-tRNA synthetase 1
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  X-prolyl aminopeptidase 1
  Yes1 associated transcriptional regulator
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.