MICB, MHC class I polypeptide-related sequence B

MICB, MHC class I polypeptide-related sequence B

• This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

• Gene Synonyms (PERB11.2, MHC class I polypeptide-related sequence B, MHC class I chain-related protein B, MHC class I mic-B antigen, MHC class I-like molecule PERB11.2-IMX, stress inducible class I homolog,)
• NCBI Gene ID: 4277
• Species: Homo sapiens (Human)
• UNIPROT ID#>>X6R344
  UNIPROT ID#>>A0A0G2JHB5
  UNIPROT ID#>>B7Z8M1
  UNIPROT ID#>>Q29980
  UNIPROT ID#>>F5H7Q8
  UNIPROT ID#>>B4DUT9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MHC class I polypeptide-related sequence B interacts with:

• BMP2 inducible kinase
  killer cell lectin like receptor C4
  killer cell lectin like receptor K1
  myosin IE
  myosin light chain 9
  ribosomal protein L36a
  ribosomal protein L37a
  SERPINE1 mRNA binding protein 1
  tripartite motif containing 25
  zinc finger CCHC-type containing 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.