MITF, melanocyte inducing transcription factor

MITF, melanocyte inducing transcription factor

• The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. [provided by RefSeq, Aug 2017]

• Gene Synonyms (CMM8, COMMAD, MI, WS2, WS2A, bHLHe32, microphthalmia-associated transcription factor, class E basic helix-loop-helix protein 32, melanogenesis associated transcription factor, microphtalmia-associated transcription factor,)
• NCBI Gene ID: 4286
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A087WXU1
  UNIPROT ID#>>Q8WYR3
  UNIPROT ID#>>O75030
  UNIPROT ID#>>B4DNC7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

melanocyte inducing transcription factor interacts with:

• EBP cholestenol delta-isomerase
  exportin 1
  F-box protein 7
  H4 clustered histone 1
  kelch like family member 20
  lymphoid enhancer binding factor 1
  mitogen-activated protein kinase 1
  orthodenticle homeobox 2
  paired box 3
  paired box 6
  POZ/BTB and AT hook containing zinc finger 1
  proteasome 26S subunit, non-ATPase 14
  protein inhibitor of activated STAT 1
  protein inhibitor of activated STAT 2
  protein inhibitor of activated STAT 3
  RB transcriptional corepressor 1
  ribosomal protein S6 kinase A1
  RNA binding motif protein 6
  small ubiquitin like modifier 1
  Spi-1 proto-oncogene
  STIP1 homology and U-box containing protein 1
  transcription factor binding to IGHM enhancer 3
  transcription factor EB
  transcription factor EC
  tripartite motif containing 25
  ubiquitin conjugating enzyme E2 I
  ubiquitin C-terminal hydrolase L1
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.