NRGN, neurogranin

NRGN, neurogranin

• Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]

• Gene Synonyms (RC3, hng, neurogranin, calmodulin-binding protein, neurogranin (protein kinase C substrate, RC3), protein kinase C substrate,)
• NCBI Gene ID: 4900
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R3M7
  UNIPROT ID#>>Q92686
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

neurogranin interacts with:

• calmodulin 1
  EF-hand calcium binding domain 7
  kelch like family member 20
  mediator complex subunit 9
  nudix hydrolase 6
  protein kinase C alpha
  protein kinase C beta
  protein kinase C gamma
  RWD domain containing 2B
  synuclein alpha
  tripartite motif containing 62
  zinc finger protein 131

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.