NUMA1, nuclear mitotic apparatus protein 1

NUMA1, nuclear mitotic apparatus protein 1

• This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

• Gene Synonyms (NMP-22, NUMA, nuclear mitotic apparatus protein 1, SP-H antigen, centrophilin stabilizes mitotic spindle in mitotic cells, nuclear matrix protein-22, structural nuclear protein,)
• NCBI Gene ID: 4926
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q3SYK8
  UNIPROT ID#>>Q14980
  UNIPROT ID#>>A0A024R5M9
  UNIPROT ID#>>Q4LE64
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nuclear mitotic apparatus protein 1 interacts with:

• abraxas 2, BRISC complex subunit
  actin related protein 1A
  Aly/REF export factor
  anterior gradient 2, protein disulphide isomerase family member
  assembly factor for spindle microtubules
  ATP binding cassette subfamily E member 1
  BAF nuclear assembly factor 1
  BRCA1 associated protein
  BRCA1/BRCA2-containing complex subunit 3
  bromodomain containing 4
  BTB and CNC homology 1, basic leucine zipper transcription factor 1
  cell division cycle 73
  chromobox 1
  chromobox 6
  chromobox 8
  coiled-coil domain containing 57
  coiled-coil domain containing 8
  cullin 7
  DDB1 and CUL4 associated factor 15
  dynein light chain LC8-type 1
  elastin microfibril interfacer 1
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  erythrocyte membrane protein band 4.1 like 3
  eukaryotic translation initiation factor 3 subunit H
  eukaryotic translation initiation factor 3 subunit I
  eukaryotic translation initiation factor 3 subunit L
  G protein signaling modulator 1
  G protein signaling modulator 2
  germ cell-less 1, spermatogenesis associated
  H2A clustered histone 4
  H3 clustered histone 1
  H4 clustered histone 1
  histone deacetylase 5
  kinesin family member 20A
  leucine rich repeat containing G protein-coupled receptor 4
  leucine rich repeats and WD repeat domain containing 1
  matrin 3
  mediator complex subunit 12
  mediator of DNA damage checkpoint 1
  M-phase phosphoprotein 8
  nicastrin
  nuclear receptor binding SET domain protein 2
  nuclear receptor coactivator 6
  nuclear receptor subfamily 2 group C member 2
  nuclear RNA export factor 1
  nucleoporin 98 and 96 precursor
  obscurin like cytoskeletal adaptor 1
  PCNA clamp associated factor
  Pim-1 proto-oncogene, serine/threonine kinase
  pleckstrin homology domain containing A4
  protein phosphatase 1 catalytic subunit gamma
  PTEN induced kinase 1
  PTTG1 regulator of sister chromatid separation, securin
  pyruvate dehydrogenase E1 subunit alpha 1
  RAD21 cohesin complex component
  RAN binding protein 2
  replication protein A1
  replication protein A2
  replication protein A3
  ribonucleic acid export 1
  ribosomal protein L35a
  ribosomal protein S13
  ring finger protein 2
  RNA polymerase II associated protein 1
  RTF1 homolog, Paf1/RNA polymerase II complex component
  RuvB like AAA ATPase 1
  serine and arginine repetitive matrix 1
  short coiled-coil protein
  signal recognition particle 72
  sirtuin 7
  SMAD specific E3 ubiquitin protein ligase 1
  small ubiquitin like modifier 2
  SSX family member 2 interacting protein
  staufen double-stranded RNA binding protein 1
  structural maintenance of chromosomes 1A
  structural maintenance of chromosomes 3
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  tankyrase
  tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
  tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
  TATA-box binding protein associated factor 15
  t-complex 10 like
  telomeric repeat binding factor 1
  telomeric repeat binding factor 2
  TERF2 interacting protein
  terminal nucleotidyltransferase 4B
  thioredoxin interacting protein
  transcription factor 7 like 2
  tripartite motif containing 28
  tumor protein p53 binding protein 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  U2 small nuclear RNA auxiliary factor 2
  valosin containing protein
  vir like m6A methyltransferase associated
  WD repeat domain 76
  WD repeat domain 83
  WW domain containing E3 ubiquitin protein ligase 2
  YEATS domain containing 4
  Yes1 associated transcriptional regulator
  zinc finger CCCH-type containing 18
  zinc finger FYVE-type containing 21

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.