OAS2, 2'-5'-oligoadenylate synthetase 2

OAS2, 2'-5'-oligoadenylate synthetase 2

• This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

• Gene Synonyms (2'-5'-oligoadenylate synthase 2, (2'-5')oligo(A) synthetase 2, 2'-5'-oligoadenylate synthetase 2, 69/71kDa, 2-5A synthase 2, p69 OAS / p71 OAS,)
• NCBI Gene ID: 4939
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q7Z6D0
  UNIPROT ID#>>P29728
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

2'-5'-oligoadenylate synthetase 2 interacts with:

• cyclic GMP-AMP synthase
  F-box protein 17
  GTPase, IMAP family member 8
  protein kinase cGMP-dependent 1
  SAM and SH3 domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.