OAS3, 2'-5'-oligoadenylate synthetase 3

OAS3, 2'-5'-oligoadenylate synthetase 3

• This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]

• Gene Synonyms (p100, p100OAS, 2'-5'-oligoadenylate synthase 3, (2-5')oligo(A) synthase 3, (2-5')oligo(A) synthetase 3, 2'-5'-oligoadenylate synthetase 3, 100kDa, 2'-5'oligoadenylate synthetase p100, 2-5A synthase 3, 2-5A synthetase 3, p100 OAS,)
• NCBI Gene ID: 4940
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y6K5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

2'-5'-oligoadenylate synthetase 3 interacts with:

• charged multivesicular body protein 1A
  chromosome 11 open reading frame 98
  coiled-coil domain containing 22
  DExH-box helicase 30
  DNA topoisomerase I
  early endosome antigen 1
  ETAA1 activator of ATR kinase
  exosome component 10
  exosome component 3
  FtsJ RNA 2'-O-methyltransferase 3
  G protein nucleolar 2
  G protein nucleolar 3
  G protein nucleolar 3 like
  G3BP stress granule assembly factor 2
  GTP binding protein 4
  interferon related developmental regulator 2
  LLP homolog, long-term synaptic facilitation factor
  Ly1 antibody reactive
  mitochondrial antiviral signaling protein
  Mtr4 exosome RNA helicase
  NOP10 ribonucleoprotein
  NOP16 nucleolar protein
  NOP53 ribosome biogenesis factor
  poly(A) binding protein cytoplasmic 4
  polypyrimidine tract binding protein 1
  pre-mRNA processing factor 19
  protein phosphatase, Mg2+/Mn2+ dependent 1G
  replication factor C subunit 4
  ribosomal protein L39
  ribosomal protein lateral stalk subunit P1
  SDA1 domain containing 1
  talin 1
  vir like m6A methyltransferase associated
  zinc finger protein 622

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.