OPRK1, opioid receptor kappa 1

OPRK1, opioid receptor kappa 1

• This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

• Gene Synonyms (K-OR-1, KOP, KOR, KOR-1, KOR1, OPRK, kappa-type opioid receptor, Opiate receptor, kappa-1, kappa opioid receptor,)
• NCBI Gene ID: 4986
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P41145
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

opioid receptor kappa 1 interacts with:

• docking protein 4
  G protein-coupled receptor associated sorting protein 1
  GABA type A receptor associated protein like 1
  siah E3 ubiquitin protein ligase 1
  siah E3 ubiquitin protein ligase 2
  SLC9A3 regulator 1
  VAMP associated protein A
  Wnt ligand secretion mediator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.