PDE1A, phosphodiesterase 1A

PDE1A, phosphodiesterase 1A

• Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]

• Gene Synonyms (calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, 61 kDa Cam-PDE, calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase, phosphodiesterase 1A, calmodulin-dependent, CAM-PDE 1A, CAM-PDE-1A, HCAM-1, HCAM1, HSPDE1A,)
• NCBI Gene ID: 5136
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z7A2
  UNIPROT ID#>>P54750
  UNIPROT ID#>>B7Z226
  UNIPROT ID#>>Q9Y633
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphodiesterase 1A interacts with:

• golgi brefeldin A resistant guanine nucleotide exchange factor 1
  phosphodiesterase 1C

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