PDE8A, phosphodiesterase 8A

PDE8A, phosphodiesterase 8A

• The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

• Gene Synonyms (high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, cAMP-specific cyclic nucleotide phosphodiesterase 8A, HsT19550,)
• NCBI Gene ID: 5151
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O60658
  UNIPROT ID#>>A0A024RC53
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphodiesterase 8A interacts with:

• nephrocystin 3
  nuclear receptor subfamily 1 group H member 3
  tripartite motif containing 25
  unc-119 lipid binding chaperone

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.