PFKFB4, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

PFKFB4, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

• The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

• Gene Synonyms (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4, 6PF-2-K/Fru-2,6-P2ase 4, 6PF-2-K/Fru-2,6-P2ase testis-type isozyme, PFK/FBPase 4, bifunctional enzyme with kinase and biphosphatase activities,)
• NCBI Gene ID: 5210
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5XLC3
  UNIPROT ID#>>B7Z5C3
  UNIPROT ID#>>Q66S35
  UNIPROT ID#>>Q16877
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 interacts with:

• cell division cycle 23
  coiled-coil domain containing 102B
  leucine rich repeat protein 1
  nuclear RNA export factor 1
  obscurin like cytoskeletal adaptor 1
  praja ring finger ubiquitin ligase 1
  protein kinase, DNA-activated, catalytic subunit
  thiosulfate sulfurtransferase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.