PKLR, pyruvate kinase L/R

PKLR, pyruvate kinase L/R

• The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (pyruvate kinase PKLR, R-type/L-type pyruvate kinase, pyruvate kinase 1, pyruvate kinase isozyme R/L, pyruvate kinase isozymes L/R, pyruvate kinase isozymes R/L, pyruvate kinase type L, pyruvate kinase, liver and RBC, pyruvate kinase, liver and blood cell, red cell/liver pyruvate kinase, PK1, PKL, PKRL, RPK,)
• NCBI Gene ID: 5313
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P30613
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pyruvate kinase L/R interacts with:

• 5'-nucleotidase domain containing 1
  copine 7
  C-type lectin domain family 4 member G
  kinesin family member 23
  mitogen-activated protein kinase 12
  muscle RAS oncogene homolog
  nuclear receptor subfamily 2 group C member 2
  OTU deubiquitinase 5
  paxillin
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  Rac/Cdc42 guanine nucleotide exchange factor 6
  transcription factor CP2
  ubiquitin specific peptidase 3
  ubiquitin specific peptidase like 1
  WW domain containing oxidoreductase
  Yes1 associated transcriptional regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.