PLCD1, phospholipase C delta 1

PLCD1, phospholipase C delta 1

• This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

• Gene Synonyms (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, PLC-delta-1, Phospholipase C I 1, epididymis secretory sperm binding protein, phosphoinositide phospholipase C-delta-1, phospholipase C-III, NDNC3, PLC-III,)
• NCBI Gene ID: 5333
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P51178
  UNIPROT ID#>>A8K8F9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phospholipase C delta 1 interacts with:

• F-box and leucine rich repeat protein 4
  GC-rich promoter binding protein 1
  growth differentiation factor 5
  hepatocyte growth factor-regulated tyrosine kinase substrate
  interleukin 31 receptor A
  kinesin family member 3A
  N-terminal glutamine amidase 1
  PAX interacting protein 1
  pyrin and HIN domain family member 1
  RAB11B, member RAS oncogene family
  RAS like proto-oncogene A
  RAS like proto-oncogene B
  RNA binding motif protein 24
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
  testis expressed 35
  transglutaminase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.