PLRG1, pleiotropic regulator 1

PLRG1, pleiotropic regulator 1

• This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

• Gene Synonyms (pleiotropic regulator 1, pleiotropic regulator 1 (PRL1 homolog, Arabidopsis), transport and golgi organization 4 homolog, Cwc1, PRL1, PRP46, PRPF46, TANGO4,)
• NCBI Gene ID: 5356
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43660
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pleiotropic regulator 1 interacts with:

• AAR2 splicing factor
  aquarius intron-binding spliceosomal factor
  BCAS2 pre-mRNA processing factor
  breast carcinoma amplified sequence 2
  carboxypeptidase vitellogenic like
  catenin beta like 1
  CD2 cytoplasmic tail binding protein 2
  cell division cycle 5-like (S. pombe)
  coiled-coil domain containing 12
  crooked neck pre-mRNA splicing factor 1
  crooked neck pre-mRNA splicing factor 1
  cullin 3
  CWC15 spliceosome associated protein homolog
  CWF19 like cell cycle control factor 2
  DEAH-box helicase 35
  DnaJ heat shock protein family (Hsp40) member C17
  double PHD fingers 2
  E2F associated phosphoprotein
  eukaryotic translation initiation factor 4A3
  exportin 1
  G-patch domain containing 1
  H4 clustered histone 1
  ISY1 splicing factor homolog
  ISY1-RAB43 readthrough
  La ribonucleoprotein 7, transcriptional regulator
  lines homolog 1
  mediator of DNA damage checkpoint 1
  mitochondrial ribosomal protein L40
  nuclear receptor subfamily 2 group C member 2
  PCF11 cleavage and polyadenylation factor subunit
  peptidylprolyl isomerase E
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 4
  PR/SET domain 16
  pre-mRNA processing factor 19
  pre-mRNA processing factor 3
  pre-mRNA processing factor 4
  pre-mRNA processing factor 8
  pre-mRNA processing factor 8
  protein disulfide isomerase family A member 5
  protein phosphatase 4 regulatory subunit 3A
  RecQ like helicase 4
  ribosomal protein L9
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 157
  ring finger protein 4
  RNA binding motif protein 14
  RNA binding motif protein 39
  serine and arginine repetitive matrix 1
  small nuclear ribonucleoprotein D2 polypeptide
  small nuclear ribonucleoprotein polypeptide A'
  small nuclear ribonucleoprotein U1 subunit 70
  SNW domain containing 1
  SNW domain containing 1
  splicing factor 3a subunit 1
  splicing factor 3a subunit 2
  splicing factor 3a subunit 3
  splicing factor 3b subunit 1
  splicing factor 3b subunit 3
  SUZ12 polycomb repressive complex 2 subunit
  SYF2 pre-mRNA splicing factor
  transcriptional adaptor 2A
  tumor suppressing subtransferable candidate 4
  U2 small nuclear RNA auxiliary factor 2
  U6 snRNA biogenesis phosphodiesterase 1
  ubiquitin C-terminal hydrolase L5
  ubiquitin specific peptidase 42
  valosin containing protein
  WW domain containing E3 ubiquitin protein ligase 2
  XPA binding protein 2
  YJU2 splicing factor homolog
  zinc finger and SCAN domain containing 1
  zinc finger CCHC-type and RNA binding motif containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.