PPP1R8, protein phosphatase 1 regulatory subunit 8

PPP1R8, protein phosphatase 1 regulatory subunit 8

• This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]

• Gene Synonyms (nuclear inhibitor of protein phosphatase 1, RNase E, activator of RNA decay, nuclear inhibitor of protein phosphatase-1 alpha, nuclear inhibitor of protein phosphatase-1 beta, nuclear subunit of PP-1, protein phosphatase 1, regulatory (inhibitor) subunit 8, ARD-1, ARD1, NIPP-1, NIPP1, PRO2047,)
• NCBI Gene ID: 5511
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6ICT4
  UNIPROT ID#>>Q12972
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein phosphatase 1 regulatory subunit 8 interacts with:

• amyloid beta precursor protein binding protein 2
  BICD cargo adaptor 2
  catenin beta like 1
  centrosomal protein 72
  embryonic ectoderm development
  ergosterol biosynthesis 28 homolog
  family with sequence similarity 98 member B
  F-box protein 25
  leucine rich repeat kinase 2
  maternal embryonic leucine zipper kinase
  peptidylprolyl isomerase like 1
  protein kinase cAMP-activated catalytic subunit alpha
  protein phosphatase 1 catalytic subunit beta
  RB binding protein 4, chromatin remodeling factor
  reticulon 4 interacting protein 1
  ring finger protein 4
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding motif protein 48
  serine hydroxymethyltransferase 2
  SET domain bifurcated histone lysine methyltransferase 1
  SHC adaptor protein 1
  small nuclear ribonucleoprotein U4/U6.U5 subunit 27
  snurportin 1
  splicing factor 3a subunit 2
  splicing factor 3b subunit 1
  stanniocalcin 2
  SUZ12 polycomb repressive complex 2 subunit
  syntaxin binding protein 1
  tripartite motif containing 28
  tumor protein p53 binding protein 1
  ubiquitin specific peptidase 47
  vacuolar protein sorting 4 homolog B
  WD repeat domain 77

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.