PRKG2, protein kinase cGMP-dependent 2

PRKG2, protein kinase cGMP-dependent 2

• This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical. [provided by RefSeq, May 2018]

• Gene Synonyms (cGMP-dependent protein kinase 2, cGMP-dependent protein kinase II, protein kinase, cGMP-dependent, type II, testicular tissue protein Li 99, PKG2, PRKGR2, cGK2, cGKII,)
• NCBI Gene ID: 5593
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VJM3
  UNIPROT ID#>>B4DLF9
  UNIPROT ID#>>B7ZA25
  UNIPROT ID#>>Q13237
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein kinase cGMP-dependent 2 interacts with:

• 6-pyruvoyltetrahydropterin synthase
  cyclin dependent kinase like 5
  F-box protein 25
  nephrocystin 3
  unc-119 lipid binding chaperone
  WD repeat domain 77

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.