PRSS3, serine protease 3

PRSS3, serine protease 3

• This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]

• Gene Synonyms (trypsin-3, brain trypsinogen, mesotrypsin, mesotrypsinogen, pancreatic trypsinogen III, protease, serine 3, protease, serine, 4 (trypsin 4, brain), trypsin III, trypsin IV, trypsinogen 4, trypsinogen 5, trypsinogen IV, MTG, PRSS4, T9, TRY3, TRY4,)
• NCBI Gene ID: 5646
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P35030
  UNIPROT ID#>>Q7Z5F4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

serine protease 3 interacts with:

• anterior gradient 2, protein disulphide isomerase family member
  double PHD fingers 2
  methyltransferase like 14
  methyltransferase like 3
  neural precursor cell expressed, developmentally down-regulated gene 1
  proteasome (prosome, macropain) subunit, beta type 5
  ribosomal protein S6 kinase B2
  ring finger and CCCH-type domains 1
  SHC adaptor protein 1
  tissue factor pathway inhibitor
  TRAF family member associated NFKB activator
  ubiquilin 2
  WT1 associated protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.