PYCR1, pyrroline-5-carboxylate reductase 1

PYCR1, pyrroline-5-carboxylate reductase 1

• This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

• Gene Synonyms (pyrroline-5-carboxylate reductase 1, mitochondrial, P5C reductase 1, proliferation-inducing protein 45, ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR,)
• NCBI Gene ID: 5831
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P32322
  UNIPROT ID#>>Q8TBX0
  UNIPROT ID#>>E2QRB3
  UNIPROT ID#>>A0A024R8U9
  UNIPROT ID#>>J3QL32
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pyrroline-5-carboxylate reductase 1 interacts with:

• apoptosis inducing factor mitochondria associated 1
  armadillo repeat containing 6
  aurora kinase A interacting protein 1
  autophagy related 16 like 1
  BAG cochaperone 3
  BCL2 interacting protein like
  caseinolytic mitochondrial matrix peptidase proteolytic subunit
  CDC16 cell division cycle 16
  CDC23 cell division cycle 23
  cell division cycle 16
  centrosomal protein 162
  centrosomal protein 78
  coiled-coil domain containing 47
  cullin 3
  cyclin dependent kinase 2 associated protein 2
  cytochrome c oxidase assembly factor COX14
  death associated protein 3
  dual specificity phosphatase 14
  elongation factor Tu GTP binding domain containing 2
  G3BP stress granule assembly factor 1
  kelch domain containing 10
  lebercilin LCA5
  mediator of DNA damage checkpoint 1
  mitochondrial rRNA methyltransferase 1
  nuclear receptor subfamily 2 group C member 2
  nucleoporin 98
  nudix hydrolase 21
  nudix hydrolase 5
  peroxiredoxin 4
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  PIH1 domain containing 1
  pyrroline-5-carboxylate reductase 2
  pyrroline-5-carboxylate reductase 3
  RecQ like helicase 4
  reticulocalbin 2
  ring finger protein 2
  SET domain containing 1A, histone lysine methyltransferase
  sideroflexin 1
  sirtuin 3
  sterol O-acyltransferase 1
  SUZ12 polycomb repressive complex 2 subunit
  synthesis of cytochrome C oxidase 1
  TNFAIP3 interacting protein 2
  transportin 2
  tripartite motif containing 14
  tRNA methyltransferase 61B
  ubiquitin C-terminal hydrolase L3
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.