RBBP6, RB binding protein 6, ubiquitin ligase

RBBP6, RB binding protein 6, ubiquitin ligase

• The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (E3 ubiquitin-protein ligase RBBP6, RB-binding Q-protein 1, RING-type E3 ubiquitin transferase RBBP6, p53-associated cellular protein of testis, proliferation potential-related protein, protein P2P-R, retinoblastoma binding protein 6, retinoblastoma-binding Q protein 1, retinoblastoma-binding protein 6, MY038, P2P-R, PACT, RBQ-1, SNAMA,)
• NCBI Gene ID: 5930
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q7Z6E9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RB binding protein 6, ubiquitin ligase interacts with:

• acyl-CoA thioesterase 13
  anaphase promoting complex subunit 16
  autophagy related 16 like 1
  calcium/calmodulin dependent serine protein kinase
  charged multivesicular body protein 4B
  cleavage and polyadenylation specific factor 1
  cleavage and polyadenylation specific factor 2
  cleavage and polyadenylation specific factor 4
  cleavage and polyadenylation specific factor 6
  cullin 1
  DEAD-box helicase 24
  DEAD-box helicase 27
  DENN/MADD domain containing 6A
  eva-1 homolog C
  FA core complex associated protein 24
  F-box and WD repeat domain containing 8
  F-box protein 7
  G1 to S phase transition 2
  H4 clustered histone 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  integrin alpha 5 (fibronectin receptor alpha)
  KH RNA binding domain containing, signal transduction associated 3
  kinesin light chain 3
  LUC7 like
  lysine methyltransferase 2E (inactive)
  Max protein
  mitotic arrest deficient 2 like 2
  mitotic spindle organizing protein 1
  MMS19 homolog, cytosolic iron-sulfur assembly component
  NDC80 kinetochore complex component
  NIMA related kinase 6
  NLR family pyrin domain containing 2
  nuclear receptor coactivator 1
  nuclear receptor subfamily 2 group C member 2
  nucleolar protein interacting with the FHA domain of MKI67
  nucleotide binding protein 2
  polo like kinase 2
  protein inhibitor of activated STAT 1
  protein kinase, AMP-activated, alpha 1 catalytic subunit
  RAD18 E3 ubiquitin protein ligase
  RCC1 like
  retinol binding protein 4
  ribosomal protein S14
  ring finger and CCCH-type domains 2
  ring finger protein 4
  RNA binding motif protein 34
  RNA binding motif protein 4
  secreted phosphoprotein 1
  serine and arginine rich splicing factor 7
  SMAD family member 3
  small nuclear ribonucleoprotein polypeptides B and B1
  small nuclear ribonucleoprotein U1 subunit 70
  SRSF protein kinase 2
  superoxide dismutase 1, soluble
  survival of motor neuron 1, telomeric
  TNFAIP3 interacting protein 2
  transformer 2 alpha homolog
  transient receptor potential cation channel subfamily C member 4 associated protein
  transmembrane p24 trafficking protein 10
  transmembrane p24 trafficking protein 2
  tubulin, gamma 1
  tumor protein p53
  tumor protein, translationally-controlled 1
  ubiquitin conjugating enzyme E2 I
  ubiquitin fold modifier 1
  UFM1 specific ligase 1
  USO1 vesicle docking factor
  vav guanine nucleotide exchange factor 2
  vir like m6A methyltransferase associated
  zinc finger and BTB domain containing 38
  zinc finger CCCH-type containing 18
  zinc finger FYVE-type containing 9
  zinc finger protein 576

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.