RGS1, regulator of G protein signaling 1

RGS1, regulator of G protein signaling 1

• This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

• Gene Synonyms (regulator of G-protein signaling 1, B-cell activation protein BL34, early response protein 1R20, epididymis secretory protein Li 87, immediate-early response 1, B-cell specific, regulator of G-protein signalling 1, 1R20, BL34, HEL-S-87, IER1, IR20,)
• NCBI Gene ID: 5996
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R945
  UNIPROT ID#>>Q08116
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

regulator of G protein signaling 1 interacts with:

• F-box protein 7
  FUN14 domain containing 2
  GIPC PDZ domain containing family member 1
  glycerophosphodiester phosphodiesterase 1
  HCLS1 associated protein X-1
  mitogen-activated protein kinase kinase kinase 12
  TSC22 domain family member 1
  UTP14A small subunit processome component

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.