RGS4, regulator of G protein signaling 4

RGS4, regulator of G protein signaling 4

• Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (regulator of G-protein signaling 4, schizophrenia disorder 9, RGP4, SCZD9,)
• NCBI Gene ID: 5999
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P49798
  UNIPROT ID#>>A0A024R909
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

regulator of G protein signaling 4 interacts with:

• COPI coat complex subunit beta 2
  phospholipase C beta 1
  prolyl endopeptidase like

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