RGS10, regulator of G protein signaling 10

RGS10, regulator of G protein signaling 10

• Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (regulator of G-protein signaling 10, regulator of G-protein signalling 10,)
• NCBI Gene ID: 6001
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43665
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

regulator of G protein signaling 10 interacts with:

• acid phosphatase 6, lysophosphatidic
  pleckstrin homology and FYVE domain containing 2
  Sin3A associated protein 18

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