RRM2, ribonucleotide reductase regulatory subunit M2

RRM2, ribonucleotide reductase regulatory subunit M2

• This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]

• Gene Synonyms (ribonucleoside-diphosphate reductase subunit M2, ribonucleotide reductase M2 polypeptide, ribonucleotide reductase small chain, ribonucleotide reductase small subunit, uncharacterized protein C2orf48, C2orf48, R2, RR2, RR2M,)
• NCBI Gene ID: 6241
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P31350
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ribonucleotide reductase regulatory subunit M2 interacts with:

• anaphase promoting complex subunit 15
  anaphase promoting complex subunit 2
  anaphase promoting complex subunit 4
  AT-rich interaction domain 2
  BICD cargo adaptor 2
  CDC16 cell division cycle 16
  CDC23 cell division cycle 23
  cell division cycle 26
  centrosomal protein 170
  COBW domain containing 1
  DEAD-box helicase 19B
  dynamin 1 like
  dynein axonemal assembly factor 5
  Fas associated factor family member 2
  FAT atypical cadherin 3
  FAT atypical cadherin 4
  fizzy and cell division cycle 20 related 1
  kinesin family binding protein
  lysine acetyltransferase 5
  MKS transition zone complex subunit 1
  NPL4 homolog, ubiquitin recognition factor
  nuclear receptor subfamily 1 group H member 4
  OFD1 centriole and centriolar satellite protein
  pleckstrin homology domain containing A4
  POC1 centriolar protein A
  protocadherin 20
  protocadherin gamma subfamily A, 11
  ribonucleotide reductase regulatory TP53 inducible subunit M2B
  RNA binding motif protein X-linked
  sodium channel and clathrin linker 1
  sperm associated antigen 9
  S-phase kinase associated protein 2
  STIL centriolar assembly protein
  succinate dehydrogenase complex assembly factor 2
  syndecan binding protein
  tetratricopeptide repeat domain 19
  transmembrane protein 248
  tripartite motif containing 25
  tumor protein p53
  valosin containing protein
  von Hippel-Lindau tumor suppressor
  WEE1 G2 checkpoint kinase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.