- Gene Overview
- Interaction Network
- Sequence Verification
ABCG8, ATP binding cassette subfamily G member 8
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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]
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Gene Synonyms (ATP-binding cassette sub-family G member 8, ATP-binding cassette, sub-family G (WHITE), member 8, sterolin 2, GBD4, STSL, STSL1,)
- NCBI Gene ID:
64241
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>Q9H221
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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ATP binding cassette subfamily G member 8 interacts with:
Paste a protein or nucleic acid sequence in the box below to confirm that it matches
this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see
how a sequence matches to an experimentally-validated ORF clone.
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