SIM1, SIM bHLH transcription factor 1

SIM1, SIM bHLH transcription factor 1

• SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or cognitive disability of Down syndrome. [provided by RefSeq, Jul 2008]

• Gene Synonyms (single-minded homolog 1, class E basic helix-loop-helix protein 14, single-minded family bHLH transcription factor 1, bHLHe14,)
• NCBI Gene ID: 6492
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P81133
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SIM bHLH transcription factor 1 interacts with:

• aryl hydrocarbon receptor nuclear translocator 2
  MAGE family member D1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.