SIM2, SIM bHLH transcription factor 2

SIM2, SIM bHLH transcription factor 2

• This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

• Gene Synonyms (single-minded homolog 2, class E basic helix-loop-helix protein 15, single-minded family bHLH transcription factor 2, transcription factor SIM2, HMC13F06, HMC29C01, SIM, bHLHe15,)
• NCBI Gene ID: 6493
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14190
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SIM bHLH transcription factor 2 interacts with:

• ariadne RBR E3 ubiquitin protein ligase 1
  aryl hydrocarbon receptor nuclear translocator 2
  forkhead box N1
  forkhead box R2
  MAGE family member D1
  matrin 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.