SIPA1, signal-induced proliferation-associated 1

SIPA1, signal-induced proliferation-associated 1

• The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]

• Gene Synonyms (signal-induced proliferation-associated protein 1, GTPase-activating protein Spa-1, p130 SPA-1, signal-induced proliferation-associated gene 1, sipa-1, SPA1,)
• NCBI Gene ID: 6494
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96FS4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

signal-induced proliferation-associated 1 interacts with:

• actin, beta
  anaphase promoting complex subunit 13
  anillin actin binding protein
  autophagy related 16 like 1
  bromodomain containing 4
  calmodulin-like 3
  COP1 E3 ubiquitin ligase
  IQ motif containing GTPase activating protein 1
  LIM domain and actin binding 1
  myosin XIX
  myosin, heavy polypeptide 9, non-muscle
  tripartite motif containing 25

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.