VPS72, vacuolar protein sorting 72 homolog

VPS72, vacuolar protein sorting 72 homolog

• The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

• Gene Synonyms (vacuolar protein sorting-associated protein 72 homolog, transcription factor-like 1, transformation suppressor gene YL-1, CFL1, Swc2, TCFL1, YL-1, YL1,)
• NCBI Gene ID: 6944
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15906
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

vacuolar protein sorting 72 homolog interacts with:

• acidic nuclear phosphoprotein 32 family member A
  acidic nuclear phosphoprotein 32 family member B
  acidic nuclear phosphoprotein 32 family member E
  ATPase H+ transporting V1 subunit G1
  calcium binding and coiled-coil domain 2
  caspase recruitment domain family member 8
  centromere protein K
  citron rho-interacting serine/threonine kinase
  coiled-coil domain containing 85B
  cytidine monophosphate N-acetylneuraminic acid synthetase
  DNA methyltransferase 1 associated protein 1
  DNA replication fork stabilization factor DONSON
  E1A binding protein p400
  EFR3 homolog A
  enhancer of polycomb homolog 1
  eukaryotic translation initiation factor 3 subunit M
  forkhead box R1
  forkhead box R2
  G protein nucleolar 3 like
  H2B clustered histone 1
  H2B clustered histone 8
  H4 clustered histone 1
  heat shock transcription factor 2 binding protein
  homeobox containing 1
  inhibitor of growth family member 3
  LEO1 homolog, Paf1/RNA polymerase II complex component
  lysine acetyltransferase 5
  mbt domain containing 1
  methionyl aminopeptidase 2
  mitotic spindle organizing protein 1
  mortality factor 4 like 1
  mortality factor 4 like 2
  MRG domain binding protein
  MYST/Esa1 associated factor 6
  nuclear factor of activated T cells 2 interacting protein
  nucleolar protein 8
  placenta enriched 1
  prolyl 4-hydroxylase subunit alpha 3
  quinolinate phosphoribosyltransferase
  RNA binding motif protein 25
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  RuvB-like protein 1
  RuvB-like protein 2
  Snf2 related CREBBP activator protein
  solute carrier family 35 member A1
  solute carrier family 39 member 9
  transformation/transcription domain associated protein
  tripartite motif containing 25
  unconventional SNARE in the ER 1
  WD repeat domain 7
  YEATS domain containing 4
  YTH domain containing 1
  zinc finger C3H1-type containing
  zinc finger HIT-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.