TFR2, transferrin receptor 2

TFR2, transferrin receptor 2

• This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

• Gene Synonyms (transferrin receptor protein 2, HFE3, TFRC2,)
• NCBI Gene ID: 7036
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UP52
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transferrin receptor 2 interacts with:

• F-box protein 6
  LRR binding FLII interacting protein 1
  mitotic arrest deficient 2 like 2
  olfactomedin 4
  peptide deformylase, mitochondrial
  SEC22 homolog A, vesicle trafficking protein
  suppressor of cytokine signaling 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.