TPH1, tryptophan hydroxylase 1

TPH1, tryptophan hydroxylase 1

• This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]

• Gene Synonyms (tryptophan 5-hydroxylase 1, L-tryptophan hydroxylase, indoleacetic acid-5-hydroxylase, tryptophan 5-monooxygenase 1, tryptophan hydroxylase (tryptophan 5-monooxygenase), TPRH, TRPH,)
• NCBI Gene ID: 7166
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P17752
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tryptophan hydroxylase 1 interacts with:

• DnaJ heat shock protein family (Hsp40) member C12
  golgi reassembly stacking protein 2
  minichromosome maintenance 10 replication initiation factor
  proline-serine-threonine phosphatase interacting protein 1
  ring finger and WD repeat domain 3
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  YEATS domain containing 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.