TPMT, thiopurine S-methyltransferase

TPMT, thiopurine S-methyltransferase

• This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]

• Gene Synonyms (thiopurine S-methyltransferase, S-adenosyl-L-methionine:thiopurine S-methyltransferase, TPMTD,)
• NCBI Gene ID: 7172
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024QZW0
  UNIPROT ID#>>P51580
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

thiopurine S-methyltransferase interacts with:

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