PAX8, paired box 8

PAX8, paired box 8

• This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

• Gene Synonyms (paired box protein Pax-8, paired domain gene 8,)
• NCBI Gene ID: 7849
• Species: Homo sapiens (Human)
• UNIPROT ID#>>R9W7C9
  UNIPROT ID#>>A0A024R4X8
  UNIPROT ID#>>Q06710
  UNIPROT ID#>>A0A024R524
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

paired box 8 interacts with:

• docking protein 4
  glial cells missing transcription factor 2
  LON peptidase N-terminal domain and ring finger 1
  serine incorporator 1
  SS18L1 subunit of BAF chromatin remodeling complex
  SUMO1 activating enzyme subunit 1
  WW domain binding protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.