PRRC2A, proline rich coiled-coil 2A

PRRC2A, proline rich coiled-coil 2A

• A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]

• Gene Synonyms (protein PRRC2A, HLA-B-associated transcript 2, large proline-rich protein BAT2, proline-rich and coiled-coil-containing protein 2A, protein G2, BAT2, D6S51, D6S51E, G2,)
• NCBI Gene ID: 7916
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P48634
  UNIPROT ID#>>A0A1U9X974
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proline rich coiled-coil 2A interacts with:

• ataxin 1 like
  autophagy related 16 like 1
  beta-transducin repeat containing E3 ubiquitin protein ligase
  bromodomain containing 7
  calcium binding and coiled-coil domain 2
  calpain 13
  cell division cycle 14A
  cleavage and polyadenylation specific factor 1
  coiled-coil-helix-coiled-coil-helix domain containing 10
  CTD phosphatase subunit 1
  C-type lectin domain containing 14A
  C-type lectin domain family 3 member A
  cullin 3
  cullin 7
  cullin associated and neddylation dissociated 1
  DEAD-box helicase 20
  DExD/H-box helicase 60
  dual specificity phosphatase 23
  elongation factor Tu GTP binding domain containing 2
  ETAA1 activator of ATR kinase
  eukaryotic translation initiation factor 3 subunit F
  eukaryotic translation initiation factor 3, subunit A
  exosome component 2
  F-box and WD repeat domain containing 11
  fucose mutarotase
  G3BP stress granule assembly factor 1
  glucosidase II alpha subunit
  golgi reassembly stacking protein 2
  H2A clustered histone 4
  H3 clustered histone 6
  inner membrane mitochondrial protein
  intraflagellar transport 88
  leucine rich repeat containing G protein-coupled receptor 4
  LUC7 like
  mitotic arrest deficient 2 like 2
  NCK adaptor protein 2
  NOP56 ribonucleoprotein
  pleckstrin homology domain containing A4
  prolyl 4-hydroxylase subunit alpha 2
  protein tyrosine phosphatase receptor type U
  RecQ like helicase 4
  rhomboid 5 homolog 2
  rhomboid domain containing 1
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  RNA binding fox-1 homolog 1
  RNA binding fox-1 homolog 2
  SEM1 26S proteasome complex subunit
  sequestosome 1
  SH3 domain containing kinase binding protein 1
  sirtuin 7
  TAR DNA binding protein
  tektin 3
  TNFAIP3 interacting protein 2
  transient receptor potential cation channel subfamily C member 4 associated protein
  translation machinery associated 16 homolog
  tubulin gamma complex associated protein 3
  ubiquitin associated protein 2 like
  vir like m6A methyltransferase associated
  WD repeat domain 77
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.